|
KMID : 0379520060220040391
|
|
한국독성학회지
2006 Volume.22 No. 4 p.391 ~ p.395
|
|
|
Antioxidant and Cytotoxicity Effects of Luteolin
|
|
Park Jin-Ny
Kang Kyung-Ah
Zhang Rui
Piao Mei Jing
Park So-Yoon
Kim Ju-Sun
Kang Sam-Sik
Hyun Jin-Won
|
|
|
Abstract
|
|
|
|
Flavonoids are polyphenolic compounds that are ubiquitous in plants. They have been shown to possess a variety of biological activities, such as antioxidant and anticancer. Reactive oxygen species (ROS) lead to damages of cellular molecules and it is the one of various factors to induce cancer. The one of flavonoids, Luteolin, was found to scavenge 1,1-diphenyl-2-piculhydrazyl (DPPH) radical and intracellular reactive oxygen species (ROS). Moreover luteolin showed protection on hamster lung fibroblast cells (V79-4 cell) damage induced by H_2O_2. And then it was investigated whether it may show cytotoxicity effect against various cancer cells by MTT, Luteolin at 10{mu}g/ml showed the cell viability of 63.2%, 34.7%, 18.4% and 71.4% against NCl-H460, HeLa, U937 and MCF-7, respectively. As a result, luteolin shows more sensitive to U937 cells among the tested cancer cell lines. In summary, luteolin has antioxidant and cytotoxicity effect or various cancer cell lines.
|
|
|
KEYWORD
|
|
|
Oxidative stress, Reactive oxygen species, Cytotoxicity
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
 
|
|